...трентал является ингибитором металлопротеиназ...
Уважаемый Иван Тимофеевич,
все же пентоксифилин скорее позиционируется в научн-мед. литературе как антицитокиновый препарат (действ. главным образом на ФНО):
Вот фрагмент статьи из полной версии и ссылки к ней:
PTX has the property of inhibiting synthesis of proinflammatory cytokines in general, although existing data suggest it may be most effective in inhibiting synthesis of TNF-alpha (8, 10, 38, 55, 61).
8.Colson A, Willems B, and Thissen JP. Inhibition of TNF- production by pentoxifylline does not prevent endotoxin-induced decrease in serum IGF-I. J Endocrinol 178: 101–109, 2003.
10.D'Hellencourt CL, Diaw L, Cornillet P, and Guenounou M. Differential regulation of TNF, IL-1, IL-6, IL-8, TNF, and IL-10 by pentoxifylline. Int J Immunopharmacol 18: 739–748, 1996
38.Marcinkiewicz J, Grabowska A, Lauterbach R, and Bobek M. Differential effects of pentoxifylline, a non-specific phosphodiesteraseinhibitor, on the production of IL-10, IL-12 p40 and p35 subunits by murine peritoneal macrophages. Immunopharmacology 49: 335–343, 2000.
55.Silva JC, Rocha MF, Lima AA, Brito GA, de Menezes DB, and Rao VS. Effects of pentoxifylline and nabumetone on the serum levels of IL-1 and TNF in rats with adjuvant arthritis. Inflamm Res 49: 14–19, 2000.
61.Voisin L, Breuille D, Ruot B, Ralliere C, Rambourdin F, Dalle M, and Obled C. Cytokine modulation by PX differently affects specific acute phase proteins during sepsis in rats. Am J Physiol Regul Integr Comp Physiol 275: R1412–R1419, 1998.
Полный текст статьи
http://ajpheart.physiology.org/cgi/content/full/286/6/H2264
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