Hyperbilirubinemia and level of thyroid hormones in a blood

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Tamara - - ---Dear doctors! Whether 50 - 70 ???y/l the hyperbilirubinemia influences function of a thyroid gland and a level of thyroid hormones in a blood of the person? In advance I thank for the answer. Tamara.

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Fadeev Valentine Viktorovich (Fadeyev) - - ---With what disease the hyperbilirubinemia is connected in this case?

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Tamara - - ---Dear Valentine Viktorovich! The Hyperbilirubinemia is connected with a persistent chronic hepatitis.

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Fadeev Valentine Viktorovich (Fadeyev) - - ---Norm or Rate of the general or common bilirubin makes 8,5 - 20,5 ???y/l. In your case it is a question about 50 - 70, that is of rising a parameter in 2 - 3,5 times. In itself rising of a level of a bilirubin will affect or influence function SHCHZH hardly. If at a hepatitis there is a disturbance belkovosinteticheskoj functions of a liver, synthesis a thyroxine-connecting or -binding of a globulin and prealbumina can be broken or disturbed. It can be reflected in the fraction of thyroid hormones connected with fibers and, thus, at a level of the general or common free connected 4. Hence, in your case, for function of a thyroid gland adequate to an estimation it is necessary to use research free 4 and, certainly TTG. To research of a level over 4 is preferred practically in any situation.

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Tamara - - ---Dear Valentine Viktorovich! Under your reference the hormonal laboratory of faculty med.radiologii RMAPO, Moscow has carried out research of level FT4 and TTG Serum of a blood: FT4=12N=13-23pmol/L; =1,8N=0,3-4,2mME/L Under the statement of employees of laboratory diagnostic sets of firm Hoffmann La-Roche Ltd were used. Why in this case to lowered level FT4 there corresponds or meets normal, instead of increased level TTG? In fact in your clause or article Thyronet/ a O?O?n?ua/hypothyrosis in section "Diagnostics" it is written: between level TTG and 4 there is a logarithmic dependence in this connection even small depression of concentration free 4 is transformed to much greater augmentation of level TTG. Thanks for the answer. Tamara.

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Melnichenko - - ---In conditions vnetiroidalnyh illnesses or diseases normal functioning of a feedback mechanism can be broken. In any case of a hypothyrosis at you is not present, as this disturbance cannot level a real hypothyrosis. It is theoretically possible to admit or allow also, that because of disturbance of function of a liver there is insufficient production of the fiber transporting 4, in this case free fiber is exposed to faster disintegration and faster transformation by cells of the pituitary body.

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Fadeev Valentine Viktorovich (Fadeyev) - - ---you very interesting patient. Meaning that without additional inquiries be interested in the firm making sets for hormonal researches. To me for these years has come already about 300 letters from patients, but.... Besides at us two floors below unit of hepathology. How much there advised both with hepatitises and with cirrhosises, from a similar sort problems did not collide or face yet. All was how is written in the Directory and not only in itself. Though all can be. Come to me on reception record on ph. 248-34-14, *lt; A HREF = and quot; mailto:walfad@cabel.net*quot; *gt; walfad@cabel.net*lt;/A*gt; with all analyses - we shall try to understand. P.S. Or come back in section for doctors

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Student MMA - - ---Having become interested in a question on possible or probable influence of the raised or increased level of a bilirubin on action of thyroxine 4, I has spent small search in database MEDLINE. The combination of keywords Bilirubin and Thyroxine contained in 115 documents. Viewing of documents of the given sample which have been published for last 10 years, has revealed following effects: 1. The competition with 4 for linkage with some transport fibers Would worsen both intracellular transportation 4, and interfabric delivery 4 in 3- organs. 2. Kataliziruja gljukuronidatsiju 4, Would accelerate inactivation 4. 3. Interaction with gangliosides and membranes of astrocytes of a brain leads so-called bilirubinovoj to an encephalopathy, and also worsens entering 4 and action 4 in various structures or frames of a brain. A conclusion: the hyperbilirubinemia renders negative influence on display of biological activity 4. Yours faithfully. Student MMA.

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Fadeev Valentine Viktorovich (Fadeyev) - - ---It is interesting. If there is a desire, open new discussion in section For doctors. I think, that at a hyperbilirubinemia of a problem arise not only with ?4... But in a clinical practice the problem, that is answers to questions, turn out, as a rule, not so refined.