Essentsialnaja Trombotsitemija and a dangerous medicine

[O.M.]

Hello,

I wish to address with a question which disturbs me some years. I live in Germany. My diagnosis Essentsialnaja Trombotsitemija. The diagnosis have put in 2000 by means of a puncturatio of an osteal brain. Then Thrombocytes were 1 600 000. Now from kolebljutsja 500 000 up to 800 000. My attending physician, the professor, the Oncologist-hematologist has appointed or nominated to me at once treatment Litalirom (Litalir = Hydroxyurea, Syrea), tsitostatik. It is known, that this preparation at long application can cause irreversible prsledstvija. The Most important - to flow in the Leukemia. Dalnejshie-changes on a skin and mutations. Therefore many doctors write out Agrilin or the Interferon. Litalir leave more likely for elderly. And me of only 35 years. I now take 2 and 3 Capsules in day serially. In my opinion, very much a greater or big dose. My Doctor (and at it or him) considers or counts wide experience, that my pavors neobosnovany and last researches not podtrerzhdajut the out-of-date opinion. And I very much experience all in this occasion. We tried to pass 2 years ago on Agrilin, but because of strong palpitation and any improvement it or he should be left. There Is only an Interferon, at which even more unpleasant accompanying signs. I very much would like to hear opinion of the Russian Hematologists. You too consider or count, what Litalir sovershennno is harmless for patients with ET?

Thankful in advance for the answer.

Olga

[Dr. Vad]

Dear Olga!



Unfortunately, if anagrelid an interferon do not approach or suit (namely pr- it is necessary to begin treatment by that with these or it, to that up to 40) the following that is gidroksiurea.

Till now it is obscure, whether is lejkemizatsija (*quot; an overflowing in ?NN???*quot;) natural disease or consequence or investigation of treatment gidrea.

[O.M.]

Thanks, Vadim Valerevich for your answer. Vobshchem, and you do not have absolute or hundred-percent confidence in Litalire. Probably all is necessary *quot; to have a seat on ?u?O*quot;. And all it is better, than to live in constant doubt and pavors. And suddenly... Though the interferon also will add additional series of unpleasant signs, and at me them already and so from- illness or disease huge quantity or amount. I shall think.

Success. Olga

[Hematolog]

... And you do not have absolute or hundred-percent confidence in Litalire. Probably all is necessary *quot; to have a seat on ?u?O*quot;.

Dear Olga!

You should not be afraid of therapy Litalirom.

By way of *quot; NONONa??n*quot; diseases in more advanced form, on my deep belief, the interferon is most adverse, if therapy from the very beginning was not spent by an interferon or was unsuccessful.

Listen to references of the attending physician - the German hematological school is very advanced in comprehension of features of current of myeloproliferative diseases.

[O.M.]

Spasibo za otvety!

[Dr. Vad]

N Engl J Med. 2005 Jul 7; 353 (1):33-45.



Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia.



Harrison CN, Campbell PJ, Buck G, Wheatley K, East CL, Bareford D, Wilkins BS, van der Walt JD, Reilly JT, Grigg AP, Revell P, Woodcock BE, Green AR; United Kingdom Medical Research Council Primary Thrombocythemia 1 Study.



Department of Haematology, University of Cambridge, and Addenbrooke's National Health Service Trust, Cambridge, United Kingdom.



BACKGROUND: We conducted a randomized comparison of hydroxyurea with anagrelide in the treatment of essential thrombocythemia. METHODS: A total of 809 patients with essential thrombocythemia who were at high risk for vascular events received low-dose aspirin plus either anagrelide or hydroxyurea. The composite primary end point was the actuarial risk of arterial thrombosis (myocardial infarction, unstable angina, cerebrovascular accident, transient ischemic attack, or peripheral arterial thrombosis), venous thrombosis (deep-vein thrombosis, splanchnic-vein thrombosis, or pulmonary embolism), serious hemorrhage, or death from thrombotic or hemorrhagic causes. RESULTS: After a median follow-up of 39 months, patients in the anagrelide group were significantly more likely than those in the hydroxyurea group to have reached the primary end point (odds ratio, 1.57; 95 percent confidence interval, 1.04 to 2.37; P=0.03). As compared with hydroxyurea plus aspirin, anagrelide plus aspirin was associated with increased rates of arterial thrombosis (P=0.004), serious hemorrhage (P=0.008), and transformation to myelofibrosis (P=0.01) but with a decreased rate of venous thromboembolism (P=0.006.) Patients receiving anagrelide were more likely to withdraw from their assigned treatment (P*lt; 0.001). Equivalent long-term control of the platelet count was achieved in both groups. CONCLUSIONS: Hydroxyurea plus low-dose aspirin is superior to anagrelide plus low-dose aspirin for patients with essential thrombocythemia at high risk for vascular events.

[O.M.]

Hello, Vadim Valerevich!



Many thanks for clause or article and that have not forgotten.:)

To my huge shame I English leaves much to be desired.;)

But just today I have read through this clause or article entirely in already translated or transferred on German a kind. There still there was very interesting article how and when it is necessary to begin treatment at ET.

Business volume, that I participate in the Internet to group for patients with majeloproliferativnymi diseases. Us already 260! Similar groups are and in other countries, in America, Holland. At us is already and the page. Here the address: www.mpd-netzwerk.de. Eto very good undertaking for us, patients. That poor or scanty and horrifying information on the Internet once 5 years ago nearly has not demented me. Now I have found answers to very many questions. For example I precisely know, that my headaches, a fibrillation in opinion of, an ache in phalanxes of fingers, chronic weariness, eto all from illness or disease and if I knew it then would not spend so much time, forces and money for circulation on every possible doctors. In group we exchange everything, that is connected with the illness or disease, useful links, we compare signs, analyses, addresses of doctors, we consult, we arrange occurrings, etc. All this so is important for us, patients, believe!

In this connection I wish to ask, someone can knows, whether there is a similar group or a forum in Russia for Essentielle Thrombozyth and * 228; mie, Polycyth and * 228; mia vera, Osteomyelofibrose. If such is not present, it or she by all means should be made.



Yours faithfully.

Olga