Dear doctor Zholudev A. ! Explain please action "Noltreks"...

[Belief]

Dear doctor Zholudev A. ! Explain please action "Noltreks". How much or As far as it is safe. Its or his what further consequences.

[Zholudev A.A.]

Rather I regret, but I have no experience of application of the given preparation. The invention new, the remote results are not known.
Noltreks
Structure:
3 measured poliakrilamid - 4, 5 1, 5 %
Bi-distilirovannaja water - 95, 5 + 1, 5 %
Ions of silver - 0, 0009 0, 0018 %
The description: Material-a biopolmer water-containing with ions of silver "Argiform" (Material BVISA) is issued under trade mark Noltreks . Highly viscous or viscid geleobraznoe the substance, not homogeneous from svetlo-yellow up to temno-brown color, possesses bactericidal properties. Owing to the unique formula the material possesses high biocompatibility with tissues of the person. Noltreks - completely a synthetic material for endoprotezirovanija sinovialnoj liquids of a joint. Does not contain ingredients of an animal parentage.

Way of action
Noltreks operates or works, restoring viscosity sinovialnoj liquids in the joints amazed or struck by an osteoarthrosis. As a result of it or this pains decrease and mobility of a joint improves. Feature of a material is greater or big duration of action in comparison with other materials filling viscosity sinovialnoj of a liquid.

Reserving
Noltreks it is intended for treatment of osteoarthrites of all large joints in any stage.

The prevention or warning and Precautions
Noltreks it is intended for use as inektsionnyj an intraarticulate preparation. To not enter into glandular educations. Repeatedly to not sterilize. To not mix or admix with other preparations.
Procedure of treatment and the devices connected with introduction Noltreks carry the minimal risk of a bleeding, the same as also other similar invasive or aggressive articulate or joint procedures. The usual precautions connected with invasive or aggressive articulate or joint procedures should be kept, namely: introduction of a material probably only in conditions pure or clean dressing-room or operational the qualified medical personnel. Noltreks it should not be applied, if there is a disease of a skin in the field of prospective introduction of a material. Do not use Noltreks with any others inektsionnymi preparations.
Introduction of a material if the joint is infected or inflamed is forbidden. Considering easy or light;mild vulnerability of tissues at Diabetum, it is necessary to concern closely or attentively to use of a material at this category of patients.
Noltreks has not been checked up among pregnant or feeding women.

Possible or Probable by-effects
After introduction Noltreks it was informed on rare or infrequent cases of a burning sensation in a joint. All cases had the easy or light;mild or moderate intensity of an expression of a painful syndrome with average duration 12 - 24 hours. The painful syndrome is stoped by reception of nonsteroid analgetics.
Adverse events
On reactions of a hypersensitivity to a preparation till now it was not informed. No painful signs proceeded more than 3 day. On adverse events we ask to inform representative NTS of "Bioforms".

Interactions
Application Noltreks in a combination with other medicines and products was not investigated or researched.

Dosage and procedure
Procedure of introduction of a material in a joint cavity is made by the qualified medical personnel in conditions pure or clean dressing-room or operational with keeping all rules of an asepsis and antiseptics as at operation.
The information for doctors! Before introduction, accurately press on the piston of a syringe until then while the small droplet to not appear on an end of a needle. Enter Noltreks only with use of a special needle 18G, being in the complete set. Before introduction of a material in a joint, it is necessary to evacuate an exsudate from its or his cavity. The same needle should be used as for excision of an exsudate, and introduction Noltreks .
Noltreks it is entered only into a cavity of a joint. However, casual introduction in soft tissues does not lead to complications.
In knee and a hip joint the material is entered under the scheme or plan: the first injection - 2, 5 ml, the second injection in a week - 5, 0 ml, at III-to her and IV-oh stages of an osteoarthrosis on sensations of the patient, the third injection is done or made in a week in a dose 5, 0 ml. Return to an initial dosage if the patient after the second injection marks or celebrates a dyscomfort is possible or probable. Within day after procedure of a load on the interested joint are limited.
In other large joints the material is entered on 2, 5 ml three times with a break into 1 week.
Course it is expedient to repeat 1 time in 12 - 24 months depending on clinical displays.
Attention!
Correct technics or technical equipment of introduction - a critical point for final result of treatment. Noltreks it is intended only for introduction by the authorized or commissioned personnel according to the legislation.
The syringe, needle and any neispolzovannyj should be destroyed immediately after a session of treatment according to the legislation of the country.
The form of delivery
Noltreks the sterile needle 18G x 1 1/2 , separately from a syringe, the instruction is delivered in a sterile plastic syringe with latch Luer-Lok packed in blister. Each syringe contains a biopolmer water-containing with ions of silver "Argiform" (BVISA) the sterilized ferry. Number of units in packing and the volume containing in each syringe, is specified on external packing.
Period of validity and conditions of storage
Term of use is specified on external packing!
To store or keep at temperature from 0 With up to + 30 With in the dry place protected from light!
To not suppose freezing and an overheat! To store or keep in a place inaccessible to children!
To not use at disturbance of integrity of sterile packing!
To not use after the termination or ending of a period of validity!

It is made
Joint-Stock Company " Centre of science " of Bioforms , of. 1103, Krasnobogatyrskaja 42, 107564, Moscow, Russia
Bodies: + 7(095) 161 05 24, the Fax: + 7(095) 161 05 24
In more detail it is possible to familiarize on a site the bioform. Look or see in the search engine jandeksa.

[child]

What is "Noltreks"?

Precisely break in an orthopedics the Russian and foreign doctors a new Russian preparation "Noltreks" .za name that "Noltreks" has received so high estimation of experts or auditeurs? First of all that owing to him disappears necessity for a surgical intervention.

"Noltreks" can replace morbid, long and not always successful operation on a prosthetic repair of joints, it is not dependent on that at what stage of development there is a disease.

Similarly to sinovialnoj liquids, "Noltreks" forms a layer between articulate or joint surfaces of bones and provides good greasing effect owing to which at the patient painful sensations disappear and there is no further destruction of a joint.



Effect "Noltreks"

How quickly passes or takes place a pain and mobility comes back?

The authentic clinical effect is fixed immediately after the first injection "Noltreks". Action of a preparation is not limited to creation of greasing effect between articulate or joint surfaces. Owing to antibacterial properties, "Noltreks" it is capable to suppress the endogenous or endogenic infections, being the reason of inflammatory processes inside of a joint.

Feature "Noltreksa" is the biological inactivity providing duration of action of a preparation. Unlike other preparations filling viscosity sinovialnoj of a liquid, "Noltreks" it is saved in a joint till 24 months and thus does not cause or cause any undesirable reactions.



Safety "Noltreks"

Owing to that the material on 100 % biosovmestim also possesses antibacterial properties, he does not render any negative influence on an organism of the person.

Data about safety of a preparation are confirmed by long-term researches in leading medical institutions, as in Russia, and zarubezhom. Till now complications or by-effects were not observed. As well as many other things injections, introduction "Noltreks" causes painful sensations. In rare or infrequent cases the easy or light;mild burning sensation in a joint immediately after introduction which some hours proceeded, however during clinical observations was observed, additional actions for a cupping of these phenomena never were required. The clinical effect was fixed without dependence from painful sensations of patients.



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