Hello! The cardiologist has written about replacement Nitrosorbota by the Monopoppy, even...

[Arina]

Hello! The cardiologist has written about replacement Nitrosorbota by the Monopoppy, even the summary the Monopoppy I can not find. Advise as to be. Thanks.

[Aptekaonline]

Hello, Arina. mono the Poppy it nitropreparat, is similar Nitrosorbitu. I send you the summary to preparation mono the Poppy:

Structure and the form of release
Tablets 1 tab.
izosorbid-5 monoSodium nitritum of 20 mg
- " - 40 mg

Other ingredients: lactose, a magnesium stearat, Talcum, cellulose microcrystallic.
10 pieces - packings jachejkovye planimetric (5) - packs cardboard.

Registration number or room:
tab. 20 mg, 40 mg: 50 pieces - P 012831/01 2001 23.03.01

Pharmacological action

Peripheric vazodilatator with primary influence on veins. An antianginal preparation. Causes decrease of a preload by a myocardium, promotes long hemodynamic unloading of a myocardium, reduces its or his need or requirement for oxygen. Expands or dilates coronary arteries and increases or enlarges a coronary blood flow, promotes its or his redistribution in subendocardial areas of a myocardium. Reduces pressure in a small circle of a circulation. Rendering the some vazodilatirujushchee action on an artery, promotes decrease of an afterload by a myocardium. Causes a relaxation of a smooth musculation of bronchuses, urinary ways, a cholic bubble, zhelchevyvodjashchih ways, an esophagus, thin and a colon, including sphincters.

Indications

- Prophylaxis and long therapy of a stenocardia;
- A chronic heart failure (in structure of the combined therapy with intimate or cardiac glycosides, diuretics, inhibitors APF, peripheric vazodilatatorami with primary influence on arterioles);
- A pulmonary hypertensia (in structure of the combined therapy).

Regimen of dosage

Therapy is expedient for beginning with application of a preparation in low doses, appointing or nominating on 10 20 mg 2 raza/days Then a dose up to 20 40 mg 1 2 raza/days if necessary probably application of a preparation in a single dose of 60 80 mg 1 2 raza/days gradually raise or increase
The interval between receptions of single doses should make not less than 8 ch.
Duration of reception of a preparation establish or install individually.

Side effect

In the beginning of treatment often there can be headaches ("nitratnaja" a headache) which usually independently disappear in some days at continuation of treatment.
From serdechno-vascular system: an arterial hypotension, a giddiness, a tachycardia, delicacy; seldom at the expressed arterial hypotension - intensifying of signs of a stenocardia (paradoxical influence of Sodium nitritums), on occassion - a collapse, bradyarrhythmia, a syncope.
From an alimentary system: seldom - a nausea, a vomiting.
Dermatologic reactions: sometimes - a transitional erubescence; on occassion - an exfoliative dermatitis.
Other: sometimes - allergic reactions; on occassion - depression of rate of psychomotor reactions.

Contraindications

- Acute disturbances of a circulation (a shock, a vascular collapse);
- A cardiogenic shock in cases when high final diastolic pressure in a left ventricle by application of an intraaortal counterpulsation or due to introduction of the preparations is not provided, having positive inotropic an effect;
- The expressed arterial hypotension (a systolic BP less than 90 mm hg, diastolic - less than 60 mm hg);
- Simultaneous reception of an inhibitor fosfodiesterazy sildenafila (viagra), as sildenafil potentsiruet antihypertensive action of Sodium nitritums;
- A hypersensibility to Sodium nitritums.

Pregnancy and lactemia

If necessary applications of preparation mono the Poppy at pregnancy and during a lactemia it is necessary to correlate carefully prospective advantage or benefit for mother and possible or probable risk for a fetus or the child in connection with absence by present or true time of the authentic clinical data confirming safety of application of a preparation during this period.

Special indicatings

Preparation do not apply to a cupping of attacks of a stenocardia.
With care apply preparation mono the Poppy at a hypertrophic subaortic stenosis, a chronic cardial compression, a tamponade of a pericardium, at low pressure of filling at an acute myocardial infarction, a left ventricular failure (in this case it is not necessary to suppose depressions of a systolic BP below 90 mm hg). At purpose or appointment of a preparation especially careful observation of the doctor is necessary for patients with aortal i/or a mitral stenosis, with predilection to orthostatic reactions, with the raised or increased intracranial pressure.
At a primary pulmonary hypertensia of an obscure etiology, and also at a coronary failure there can come or step the time or temporary anoxemia caused by intensifying of a blood flow in pulmonary segments with a hypoventilation.
At long continuous application of Isosorbidum of monoSodium nitritum in high doses probably development of tolerance to a preparation, and also occurrence of two-dimensional tolerance in relation to other Sodium nitritums. Therefore treatment by high doses should be spent with breaks and to not appoint or nominate a preparation more often 2 raz/days
Application of preparation mono the Poppy can lead to a transitional anoxemia due to relative redistribution of a blood flow in gipoventiliruemye alveolar segments that can become a releaser of development of an ischemia of a myocardium at patients from an ischemic heart disease.
The cancelling of a preparation should be spent gradually in order to prevent development of a withdrawal.
On a tablet there is a dividing groove that facilitates individual selection of a dose.
During application of a preparation it is not necessary to take alcohol.
Use in pediatrics
Efficiency and safety of application of a preparation at children is not established or installed.
Influence on ability to driving motor transport and to management of mechanisms
During treatment depression of rate of psychomotor reactions in this connection it is not recommended to drive vehicles is possible or probable and to be engaged in other potentially dangerous kinds of activity.

Overdosage

Signs: depression of a BP with an orthostatic hypotension, a reflex tachycardia, a headache. The asthenia, a giddiness, a sleepiness, inflow, a nausea, a vomiting are possible or probable. At a chronic overdosage rising a level of a methemoglobin is possible or probable.
Treatment: a gastric lavage; the patient should give horizontal position with raised head over heels; the control and, if necessary, correction of the vital functions of an organism is necessary. At the expressed arterial hypotension i/or a shock it is possible to enter blood substitutes, and also Noradrenalinum i/or Dopaminum. The adrenaline and its or his preparations in such cases are counter-indicative. At a serious methemoglobinemia the oxygenotherapy, a hemodialysis, a metabolic hemotransfusion is recommended; in easier or lighter;more mild cases appoint or nominate Acidum ascorbinicum (1 g inside or v/in in the form of sodic salt); metilenovyj dark blue (v/in up to 50 ml 1 % of a solution); toluidin dark blue (all over again v/in fast at the rate of 2 4 mg/the kg of mass of a body, then if necessary repeated enter in a dose at the rate of 2 mg/kg with intervals between introductions in 1).

Medicinal interaction

At simultaneous application mono of the Poppy with antihypertensive agents, beta-adrenoblockers, blockers of calcium channels, an inhibitor fosfodiesterazy sildenafilom (viagra), neuroleptics, tritsiklicheskimi antidepressants and with ethanol probably intensifying of antihypertensive action of preparation mono the Poppy.
At simultaneous application mono of the Poppy and digidroergotamina intensifying hypertensive action and rising of concentration digidroergotamina in a blood plasma is possible or probable.
At simultaneous application mono of the Poppy and Noradrenalinum the therapeutic effect of the last decreases.
Yours faithfully, Svetlana Vladimirovna.