The analysis of DNA of a kernel or core of a spermatozoon

[ALNA]

Good afternoon!



We are surveyed with the husband in occasion of sterility or barrenness. Have made expanded spermogrammu.

Volume - 3 ml

pH - 7.2

Concentration in 1 ml. - 21 *10 (6) norm or rate from 20 ???./ml

Mobile - 8 %

slabopodvizhnyh - 40 %

Motionless - 5 %

Dead - 47 %

Parity or Ratio ??a?y?UO/pathological - 1/99:-(



1. Abnormal:

vytjanutyh-38 %

Amorphous - 59 %

Others - 2 %

2. Another:

With a pathology of a tail - 10 %

With a pathology compare parts - 40 %



The doctor has told or said, that only IKSI.

But before IKSI it is necessary to make the analysis of DNA of a kernel or core of a spermatozoon to exclude wrong DNA.

What is this the analysis such where it is possible to esteem about it or him?

Whether also it is possible to do or make IKSI if DNA will be wrong?

[boris]

Uv. ALNA!







But before IKSI it is necessary to make the analysis of DNA of a kernel or core of a spermatozoon to exclude wrong DNA.

One of the reasons of disturbance of a spermatogenesis can be microdeletions AZF of a locus in Y to a chromosome. These disturbances can not only peredovatsja by right of succession to sons, but also to cause more serious genetic disturbances. For exception of this reason and to be spent -genetic analysis AZF of subregions at patients with oligoastenozoospermiej a serious degree.



Whether also it is possible to do or make IKSI if DNA will be wrong?



Application donor programmm is recommended

[ALNA]

Thanks for the answer.



Not so clearly that such *quot; microdeletion AZF of a locus in Y OO???N*quot;. What probability, what DNA will be wrong at our analyses? (99 % patologich. Forms)

Such -in patologich. Forms directly it is connected with possible or probable bad DNA?



Excuse for silly questions, I in it or this a little that understand, but for us it is important for knowing.



I have understood only, that if the analysis of DNA will be bad IKSI to do or make it is impossible, since 100 % probability to conceive genetically sick child.

And more a question: if DNA of one spermatozoon will appear wrong it means, what all spermatozoons carry in themselves genic disturbances? And then only the donorship will help or assist?

[boris]

Uv. ALNA!

Really without special honey. It is enough education slozhnorazobratsja in terminology, but you of it or this also do not need to do or make. It is unique important questions for you in the given situation the question on that is exists or not such genetic *quot; ??a*quot; in Y to a chromosome of your spouse and proceeding from it or this the decision on an opportunity of carrying out ICSI or makes of application of a donor semen.

[ALNA]

Thanks.



Still voprosik, it is possible?

In family of the husband there were no genetic diseases.

This possible or probable genetic breakage in Y to a chromosome could occur or happen in itself? (if she is certainly)

Before delivery of the analysis to wait some more weeks... Present our status....





And you accept in Ava-? If yes, at you in clinic do or make the analysis of DNA or you somewhere send?

[boris]

Uv. ALNA!



This possible or probable genetic breakage in Y to a chromosome could occur or happen in itself?



It is valid so. Not including sparodichechskih cases when pregnancy from the men having such mutation, has occured or happened itself and transfers, owing to carrying out IKSI, the majority to concern to again arisen (de novo) to mutations.



We cooperate with genetic laboratory Ottovskogo of institute where we carry out this research.

[ALNA]

Thanks.

Sadly somehow: (

[ALNA]

Uv. boris!



Prompt where it is possible to make the analysis of microdeletion AZF of a locus in Y to a chromosome. This same, what the analysis of DNA of a kernel or core of a spermatozoon or not?

It is desirable in Moscow.

[boris]

Unfortunately I do not own the information across Moscow. In SPb now you can spend this research at us in clinic.

[Medvedeva]

In Moscow mikrodeletsionnyj the analysis of locus AZF (the genetic test) spend in laboratory EKO of the Center of planning of family and a reproduction (the Sevastopol prospectus).



Yours faithfully,

Medevedeva