The first child is sick - a congenital retinoblastoma of both eyes. What verojatn...

[Oksana]

The first child is sick - a congenital retinoblastoma of both eyes. What probability of a birth of the second child with the same pathology, what analyses it is possible to make?

[Talanova E.J.]

Dear Oksana! First of all, it is important, whether is (let even minimally shown) attributes of congenital disturbance of a retina at parents. Frequently simply ophthalmologist can establish or install it only skilled or experienced sindromolog, instead of at scheduled survey. If such attributes are, probability of a birth of the child with a retinoblastoma - 50 %. If the most careful survey of parents has revealed nothing, the probability of a birth of the child with a retinoblastoma is believed with 5 %. I do not know, where is applied (and whether is applied) molekuljarno-genetic testing of the given defective gene in Russia, but in the West it or him apply. But to begin, certainly, it is necessary from inspection of eyes of parents skilled or experienced genetikom-sindromologom.