Астма передасться?

[Nikolas]

Скажите какой процент передачи астмы ребенку? У папы астам с 4 лет, аллергия на пыль, перо, шерсть, цветения, лекарства. Ну вообщем аллергик.

Есть ли какие то профилактические меры, чтоб избежать передачи астмы?

Сейчас беременна.

[гена]

Предрасположенность к развитию бронхиальной астмы наследуется.

Предупредить каким-то образом "передачу астмы по наследству" нельзя.



Но надо надеяться на лучшее, совершенно не обязательно, что ребенок будет болеть.

[Ада]

А почему астма может проявиться влюбом возрасте. Например у бабушки мужа она проявилась в 70 лет!, у его мамы - в 50, у него в 4. С чем это связано?

[1Оксана1]

Наследуется предрасположенность к заболеванию. Эту предрасположенность можно реализовать, а можно не реализовать.

Сложно предсказать, что может спровоцировать развитие болезни у конкретного человека и в каком возрасте это произойдет.

[Galina28]

Semin Respir Crit Care Med. 2002;23(4):331-8.



The genetics of asthma.



Wechsler ME, Israel E.



Harvard Medical School, Cambridge, Massachusetts, and Pulmonary Division, Brigham and Women's Hospital, Boston, Massachusetts.



Asthma is a complex respiratory disease that, based on familial aggregation studies, has long been recognized to have a significant genetic component. Understanding the genetics of asthma is complicated by the fact that there are multiple different pathophysiological mechanisms leading to a complicated heterogeneous phenotype that is difficult to define. It is generally recognized as a complex genetic disease that cannot be explained by single gene models, and in most cases it appears to result from the interaction of multiple genetic and environmental factors. Although linkage and association studies have demonstrated several important relationships between asthma and a variety of genetic loci, no single gene or group of genes has been definitively demonstrated to be responsible for asthma. However, population studies, candidate gene approaches, genome-wide screens, and pharmacogenetic studies have all resulted in an increased understanding of the complexities of asthma genetics and may lead to better preventive strategies, diagnostic tools, and therapies for this disease.





Semin Respir Crit Care Med. 2003;24(2):185-96.



Genetics of environmental asthma.



Zaas D, Schwartz DA.



Pulmonary and Critical Care Division, Department of Medicine; Department of Veterans Affairs Medical Center; and Duke University Medical Center, Durham, North Carolina.



The prevalence of asthma continues to increase throughout Western societies and now is estimated to affect nearly 10% of Americans. Asthma is a syndrome that results when a genetically susceptible individual is exposed to specific allergens, which triggers airway inflammation, bronchial hyperresponsiveness, and airway remodeling. Family and twin studies have shown that there is a major genetic component to the development of asthma and have attempted to determine the heritable risk. Linkage analysis has identified several areas of interest on multiple different chromosomes that have been associated with different asthma phenotypes. Candidate gene studies have looked at specific gene polymorphisms that are associated with the development of asthma. Finally, several genes are associated with the development of asthma in response to specific environmental allergen exposures. Asthma is a heterogeneous collection of diseases that can result from multiple different pathological processes. The inheritance of asthma is complex and not due to a single gene mutation. Rather, asthma appears to be the result of multiple genetic mutations that influence an individual's susceptibility to develop asthma in response to specific allergens.